Vitamin B12 Deficiency: What are the consequences?

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Scientific publications Vitamin B12 Deficiency and Multiple Sclerosis

  1. Reynolds EH. Multiple sclerosis and vitamin B12 metabolism. J Neuroimmunol. 1992 Oct;40(2-3):225-30. Review.

  2. Reynolds EH, Bottiglieri T, Laundy M, Crellin RF, Kirker SG. Vitamin B12 metabolism in multiple sclerosis. Arch Neurol. 1992 Jun;49(6):649-52

  3. Reynolds EH, Linnell JC, Faludy JE. Multiple sclerosis associated with vitamin B12 deficiency. Arch Neurol. 1991 Aug;48(8):808-11

  4. Aksungar FB, Topkaya AE, Yildiz Z, Sahin S, Turk U. Coagulation status and biochemical and inflammatory markers in multiple sclerosis. J Clin Neurosci. 2008 Apr;15(4):393-7. Epub 2008 Feb 6.

  5.  Attenuation of experimental autoimmune encephalomyelitis and nonimmune demyelination by IFN-beta plus vitamin B12: treatment to modify notch-1/sonic hedgehog balance. J Immunol. 2004 May 15;172(10):6418-26.

  6.  Besler HT, Comoğlu S. Lipoprotein oxidation, plasma total antioxidant capacity and homocysteine level in patients with multiple sclerosis. Nutr Neurosci. 2003 Jun;6(3):189-96.

  7.  Bottiglieri T, Hyland K, Reynolds EH. The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders. Drugs. 1994 Aug;48(2):137-52.

  8.  Bottiglieri T. Folate, vitamin B12, and neuropsychiatric disorders. Nutr Rev. 1996 Dec;54(12):382-90. Review.

  9.  Bowling AC, Stewart TM. Current Complementary and Alternative Therapies for Multiple Sclerosis. Curr Treat Options Neurol. 2003 Jan;5(1):55-68.

  10.  Calabresi PA. Diagnosis and management of multiple sclerosis. Am Fam Physician. 2004 Nov 15;70(10):1935-44. Review.

  11.  Clausen J. Mercury and multiple sclerosis. Acta Neurol Scand. 1993 Jun;87(6):461-4.

  12.  Frequin ST, Wevers RA, Braam M, Barkhof F, Hommes OR. Decreased vitamin B12 and folate levels in cerebrospinal fluid and serum of multiple sclerosis patients after high-dose intravenous methylprednisolone. J Neurol. 1993 May;240(5):305-8.

  13.  Ghezzi A, Zaffaroni M. Neurological manifestations of gastrointestinal disorders, with particular reference to the differential diagnosis of multiple sclerosis. Neurol Sci. 2001 Nov;22 Suppl 2:S117-22. Review.

  14.  Goodkin DE, Jacobsen DW, Galvez N, Daughtry M, Secic M, Green R. Serum cobalamin deficiency is uncommon in multiple sclerosis. Arch Neurol. 1994 Nov;51(11):1110-4.

  15.  Goodkin DE, Jacobsen DW, Green R. Biologically significant serum vitamin B12 deficiency in multiple sclerosis inadequately documented. Arch Neurol. 1992 Jul;49(7):683-4.

  16.  Gruener DM, Kunkel EJ, Snyderman DA, Infante MR, Rodgers C, Field HL. Dietary vitamin B12 deficiency in a patient with multiple sclerosis. Gen Hosp Psychiatry. 1994 May;16(3):224-8.

  17.  Gupta JK, Ingegno AP, Cook AW, Pertschuk LP. Multiple sclerosis and malabsorption. Am J Gastroenterol. 1977 Dec;68(6):560-5.

  18. Health News. 2002 Nov;8(11):4. No abstract available.

  19.  Hemendinger RA, Armstrong EJ 3rd, Brooks BR. Methyl Vitamin B12 but not methylfolate rescues a motor neuron-like cell line from homocysteine-mediated cell death. Toxicol Appl Pharmacol. 2011 Mar 15;251(3):217-25. Epub 2011 Jan 13.

  20.  Hosp Pract (Minneap). 1995 Jul 15;30(7):47-52; discussion 52, 54.

  21. J Neurol. 2008 Jan;255(1):64-9. Epub 2007 Dec 20.

  22.  Kira J, Tobimatsu S, Goto I. Vitamin B12 metabolism and massive-dose methyl vitamin B12 therapy in Japanese patients with multiple sclerosis. Intern Med. 1994 Feb;33(2):82-6.

  23.  Kocer B, Engur S, Ak F, Yilmaz M. Serum vitamin B12, folate, and homocysteine levels and their association with clinical and electrophysiological parameters in multiple sclerosis. J Clin Neurosci. 2009 Mar;16(3):399-403. Epub 2009 Jan 18.

  24.  Krumholz A, Weiss HD, Goldstein PJ, Harris KC. Evoked responses in vitamin B12 deficiency. Ann Neurol. 1981 Apr;9(4):407-9.

  25.  Krupp L. Managing MS. While a cure is sought, people with MS can help themselves.

  26.  Loder C, Allawi J, Horrobin DF. Treatment of multiple sclerosis with lofepramine, L-phenylalanine and vitamin B(12): mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems. Med Hypotheses. 2002

  27.  Loder C, Allawi J, Horrobin DF. Treatment of multiple sclerosis with lofepramine, L-phenylalanine and vitamin B(12): mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems. Med Hypotheses. 2002 Nov;59(5):594-602.

  28.  Mastronardi FG, Min W, Wang H, Winer S, Dosch M, Boggs JM, Moscarello MA. Neurol Sci. 2001 Nov;22 Suppl 2:S98-102. Review.

  29.  Mastronardi FG, Tsui H, Winer S, Wood DD, Selvanantham T, Galligan C, Fish EN, Dosch HM, Moscarello MA. Synergy between paclitaxel plus an exogenous methyl donor in the suppression of murine demyelinating diseases. Mult Scler. 2007 Jun;13(5):596-609. Epub 2007 Feb 9.

  30.  Miller A, Korem M, Almog R, Galboiz Y. Vitamin B12, demyelination, remyelination and repair in multiple sclerosis. J Neurol Sci. 2005 Jun 15;233(1-2):93-7.

  31.  Nijst TQ, Wevers RA, Schoonderwaldt HC, Hommes OR, de Haan AF. Vitamin B12 and folate concentrations in serum and cerebrospinal fluid of neurological patients with special reference to multiple sclerosis and dementia. J Neurol Neurosurg Psychiatry. 1990 Nov;53(11):951-4.

  32.  Prabhakar S, Syal P, Singh P, Lal V, Khandelwal N, Das CP. Non-compressive myelopathy: clinical and radiological study. Neurol India. 1999 Dec;47(4):294-9.

  33.  Qaiyum M, Sandrasegaran K. Post-operative paraesthesia. Br J Radiol. 2000 Jul;73(871):791-2. No abstract available.

  34.  Ramsaransing GS, Fokkema MR, Teelken A, Arutjunyan AV, Koch M, De Keyser J. Plasma homocysteine levels in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2006 Feb;77(2):189-92.

  35.  Reynolds E. Vitamin B12, folic acid, and the nervous system. Lancet Neurol. 2006 Nov;5(11):949-60. Review.

  36.  Reynolds EH, Bottiglieri T, Laundy M, Crellin RF, Kirker SG. Vitamin B12 metabolism in multiple sclerosis. Arch Neurol. 1992 Jun;49(6):649-52.

  37.  Reynolds EH, Bottiglieri T, Laundy M, Crellin RF, Kirker SG. Vitamin B12 metabolism in multiple sclerosis. Arch Neurol. 1992 Jun;49(6):649-52.

  38.  Reynolds EH, Linnell JC, Faludy JE. Multiple sclerosis associated with vitamin B12 deficiency. Arch Neurol. 1991 Aug;48(8):808-11.

  39.  Reynolds EH. Multiple sclerosis and vitamin B12 metabolism. J Neuroimmunol. 1992 Oct;40(2-3):225-30. Review.

  40.  Reynolds EH. Multiple sclerosis and vitamin B12 metabolism. J Neurol Neurosurg Psychiatry. 1992 May;55(5):339-40. Review.

  41.  Russo C, Morabito F, Luise F, Piromalli A, Battaglia L, Vinci A, Trapani Lombardo V, de Marco V, Morabito P, Condino F, Quattrone A, Aguglia U. Hyperhomocysteinemia is associated with cognitive impairment in multiple sclerosis.

  42.  Sandyk R, Awerbuch GI. Nocturnal melatonin secretion in multiple sclerosis patients with affective disorders. Int J Neurosci. 1993 Feb;68(3-4):227-40. Review.

  43.  Sandyk R, Awerbuch GI. Vitamin B12 and its relationship to age of onset of multiple sclerosis. Int J Neurosci. 1993 Jul-Aug;71(1-4):93-9.

  44.  Scalabrino G, Galimberti D, Mutti E, Scalabrini D, Veber D, De Riz M, Bamonti F, Capello E, Mancardi GL, Scarpini E. Loss of epidermal growth factor regulation by cobalamin in multiple sclerosis. Brain Res. 2010 May 28;1333:64-71. Epub 2010 Mar 27.

  45.  Scalabrino G. Cobalamin (vitamin B(12)) in subacute combined degeneration and beyond: traditional interpretations and novel theories. Exp Neurol. 2005 Apr;192(2):463-79. Review. Erratum in: Exp Neurol. 2005 Aug;194(2):561.

  46.  Schilling RF, Williams WJ. Vitamin B12 deficiency: underdiagnosed, overtreated?

  47.  Tremlett HL, Luscombe DK, Wiles CM. Prescribing for multiple sclerosis patients in general practice: a case-control study. J Clin Pharm Ther. 2001 Dec;26(6):437-44.

  48.  Triantafyllou N, Evangelopoulos ME, Kimiskidis VK, Kararizou E, Boufidou F, Fountoulakis KN, Siamouli M, Nikolaou C, Sfagos C, Vlaikidis N, Vassilopoulos D. Increased plasma homocysteine levels in patients with multiple sclerosis and depression. Ann Gen Psychiatry. 2008 Sep 9;7:17.

  49.  Trojano M, Paolicelli D. The differential diagnosis of multiple sclerosis: classification and clinical features of relapsing and progressive neurological syndromes. Neurol Sci. 2001 Nov;22 Suppl 2:S98-102

  50.  van Rensburg SJ, Kotze MJ, Hon D, Haug P, Kuyler J, Hendricks M, Botha J, Potocnik FC, Matsha T, Erasmus RT. Iron and the folate-vitamin B12-methylation pathway in multiple sclerosis. Metab Brain Dis. 2006 Sep;21(2-3):121-37. Epub 2006

  51.  Vrethem M, Mattsson E, Hebelka H, Leerbeck K, Osterberg A, Landtblom AM, Balla B, Nilsson H, Hultgren M, Brattström L, Kågedal B. Increased plasma homocysteine levels without signs of vitamin B12 deficiency in patients with multiple sclerosis assessed by blood and cerebrospinal fluid homocysteine and methylmalonic acid. Multiple Sclerosis 2003 9, 239-45

  52.  Ghezzi A, Zaffaroni M. Neurological manifestations of gastrointestinal disorders, with particular reference to the differential diagnosis of multiple sclerosis. Neurol Sci. 2001 Nov;22 Suppl 2:S117-22. Review.

  53.  Wade DT, Young CA, Chaudhuri KR, Davidson DL. A randomised placebo controlled exploratory study of vitamin B-12, lofepramine, and L-phenylalanine (the "Cari Loder regime") in the treatment of multiple sclerosis. J Neurol Neurosurg Psychiatry. 2002 Sep;73(3):246-9.

  54.  Wilhelm H, Grodd W, Schiefer U, Zrenner E. Uncommon chiasmal lesions: demyelinating disease, vasculitis, and cobalamin deficiency. Ger J Ophthalmol. 1993 Aug;2(4-5):234-40.

  55.  Wynn M, Wynn A. The danger of B12 deficiency in the elderly. Nutr Health. 1998;12(4):215-26. Review.

  56.  Zhu Y, He ZY, Liu HN. Meta-analysis of the relationship between homocysteine, vitamin B(12), folate, and multiple sclerosis. J Clin Neurosci. 2011 May 11. [Epub ahead of print]

Further Information on MS

Check out the following sites for further information on MS

http://www.mult-sclerosis.org/whatisms.html

http://www.msif.org/en/about_ms/what_is_ms.html